Metals in medicine

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  • Created by: SamDavies
  • Created on: 25-04-19 22:46
Which orbital block contains elements found in trace quantities which are key participants in electron transfer reactions, respiratory chain, O2 storage and transport?
d
1 of 11
Which metalloprotein has an Fe centre, is octahedral with binding site X, and is involved in phase I metabolism?
CYP450
2 of 11
Which metalloprotein has a Co centre, is octahedral in shape, has 1 nitrogen from dimethylbenzimidazole, and is key in DNA synthesis?
Cobalamin
3 of 11
Which metalloprotein has a Zn centre, tetrahedral with 3 N from histidine ligands and 1 active site, and catalyses the conversion between CO2 and H2O into bicarbonate
Carbonic anhydrase
4 of 11
Which metalloprotein can have a Cu/Zn (SOD1) or Mn (SOD2) centre, is trigonal bipyramidal in shape, and converts oxygen free radicals in H2O2?
Superoxide dismutase
5 of 11
What can be observed in a mass spec of a metalloprotein?
Isotopic pattern
6 of 11
What is the name of the technique in which a signal is produced when symmetrical vibrations are absorbed which also allows the molecule to be in aqueous solution?
RAMAN
7 of 11
Lipinski's rules apply to metals. True or false?
False
8 of 11
What are the chloride concentrations in the plasma, a cell and a nucleus in that order?
150mM, 60mM, 20mM
9 of 11
Cisplatin cannot undergo phase I or II metabolism. True or false?
True
10 of 11
Why is oxaliplatin better than cisplatin?
Both
11 of 11

Other cards in this set

Card 2

Front

Which metalloprotein has an Fe centre, is octahedral with binding site X, and is involved in phase I metabolism?

Back

CYP450

Card 3

Front

Which metalloprotein has a Co centre, is octahedral in shape, has 1 nitrogen from dimethylbenzimidazole, and is key in DNA synthesis?

Back

Preview of the front of card 3

Card 4

Front

Which metalloprotein has a Zn centre, tetrahedral with 3 N from histidine ligands and 1 active site, and catalyses the conversion between CO2 and H2O into bicarbonate

Back

Preview of the front of card 4

Card 5

Front

Which metalloprotein can have a Cu/Zn (SOD1) or Mn (SOD2) centre, is trigonal bipyramidal in shape, and converts oxygen free radicals in H2O2?

Back

Preview of the front of card 5
View more cards

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