in regards to Events leading to chronic infection; Pseudomonas deposited on mucus surface penetrates into what zones within the mucus.
hypoxic
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what resist secondary defences, including neutrophils, setting the stage for chronic infection. Increased numbers of bacteria and neutrophils render the mucus hypoxic.
Macrocolonies
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what is the Barrier to phagocytes; inhibits complement and antibody binding
Mucoid exopolysaccharide (alginate)
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activation of what results in the production of cytokines by the pulmonary macrophage and by the epithelial cell?
TLR4 (TOLL-LIKE RECEPTOR)
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ACTIVATION OF TLR4 RESULTS IN PRODUCTION OF WHAT
IL8
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WHAT ACTIVATES EPITHELIUM TO PRODUCE MORE IL8 AND RECRUIT MORE NEURTOPHILS
NEUTROPHIL ELASTASE
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CF IS CAUSED BY A PROTEASE/ ANTIPROTEASE IMBALANCE. WHAT IS THERE EXCESS OF?
PROTEASE
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WHAT ARE THE PROTEASES REPONSISBLE FOR
TISSUE INJURY
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WHAT IS THERE ALSO AN IMBALANCE OF IN ADDITION TO TISSUE INJURY/TISSUE PROTECTION AND PROTEASE/ANTIPROTEASE?
OXIDANT/ANTIOXIDANT
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NEUTROPHIL ELASTASE SELF-AMPLYFYING CYCLE OF NEUTROPHIL RECRUITMENT THRU RELEASE OF IL8. THIS CAUSES A CLEAVAGE OF WHAT TO RESULT IN THE FAILURE OF OPSONISATION AND PHAGOCYTOSIS?
C3b AND IgG
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CF HAS PLUGGING IN AIRWAYS (OBSTRUCTION) CAUSED BY WHAT?
DEHYDRATED MUCOUS SECRETIONS
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ELASTASE DEGRADES ELASTIN WHICH IS IMPORTANT FOR BRONCHIAL FUNTION DUE TO ITS ELASTIC PROPERTIES, IT CONTRIBUTES TO THE IMBALANCE IN ION AND WATER MOVEMNT DUE TO ACTUVATING WHAT
EPITHELIUM SODIUM CHANNEL
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DEFICIENCY IN CFTR MEANS INCREASE IN NA+ ABSORPTION AND DECREASE IN WHAT SECRETION
Cl-
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Other cards in this set
Card 2
Front
what resist secondary defences, including neutrophils, setting the stage for chronic infection. Increased numbers of bacteria and neutrophils render the mucus hypoxic.
Back
Macrocolonies
Card 3
Front
what is the Barrier to phagocytes; inhibits complement and antibody binding
Back
Card 4
Front
activation of what results in the production of cytokines by the pulmonary macrophage and by the epithelial cell?
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