cystic fibrosis 12Therapeutic strategies for CF

Get Revising

Created by: LailaFrancis
Created on: 27-02-23 19:26

Treatment of lung disease in Cystic Fibrosis in methods of Reducing airway obstruction, select wrong statement

corticosteroids

1 of 16

sputum is defined as what

mucus + debris of inflamm. response

2 of 16

what are mucins

glycoproteins, protein core heavily glycosylated large molecules joined end to end by disulphide bonds

3 of 16

mucolytics: select incorrect mucolytic

elexacaftor

4 of 16

Maintenance therapy with inhaled colistin or WHAT to reach high airway concentrations

aminoglycosides

5 of 16

what are corticosteroids not effective in CF

CF is a neutrophillic inflammatory reaction.

6 of 16

NSAIDs also not effective as they induce the synthesis of pro-inflammatory cytokines. Anti-protease. Neutrophil elastase is an important target for therapy. - Therapies based on the natural elastase inhibitors, include recombinant alpha1-antitrypsin (alp

neutrophil elastase should outweigh antiproteases

7 of 16

CF would seem an excellent candidate for gene therapy as it a single-gene defect and therapy can be directly applied to the most obvious cellular target, the airway epithelial cells. Viral (adenovirus) and non-viral (liposomal) WHAT have been used to tran

vectors

8 of 16

to modify the basic defect of CF, you can alter other channels e.g Na, name a drug that can do this? (but not majorly effective solo)

amiloride

9 of 16

what can activate mutant CFTR?

CFTR modulators

10 of 16

membrane permeable. taken into ER where CFTR proteins are made. what drug corrected misfiled CFTR proteins and directed them to the Golgi for glycosylation?

Lumacaftor

11 of 16

many CFTR modulating drugs, varying from potentiators, to correctors to combos of the 2: select incorrect answer

mannitol

12 of 16

improve hydration of mucus

mannitol

13 of 16

thin mucus

DNase

14 of 16

what can prevent the defective CF gene

gene therapy

15 of 16

prevents inflammation in CF

NSAIDS/steroids, anti-elastase, anti-oxidants

16 of 16

Other cards in this set

Card 2

Front

sputum is defined as what

Back

mucus + debris of inflamm. response

Card 3

Front

what are mucins

Back

Card 4

Front

mucolytics: select incorrect mucolytic

Back

Card 5

Front

Maintenance therapy with inhaled colistin or WHAT to reach high airway concentrations

Back

View more cards

Get Revising

cystic fibrosis 12Therapeutic strategies for CF