cystic fibrosis 11 CFTR function in the airway and airway inflammationin CF

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1. NEUTROPHIL ELASTASE SELF-AMPLYFYING CYCLE OF NEUTROPHIL RECRUITMENT THRU RELEASE OF IL8. THIS CAUSES A CLEAVAGE OF WHAT TO RESULT IN THE FAILURE OF OPSONISATION AND PHAGOCYTOSIS?

  • C3b AND IgG
  • C3b AND IgA
  • C2b AND IgG
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2. in regards to Events leading to chronic infection; Pseudomonas deposited on mucus surface penetrates into what zones within the mucus.

  • hypoxic
  • hypnotic
  • hypotonic
  • hypotonic

3. ELASTASE DEGRADES ELASTIN WHICH IS IMPORTANT FOR BRONCHIAL FUNTION DUE TO ITS ELASTIC PROPERTIES, IT CONTRIBUTES TO THE IMBALANCE IN ION AND WATER MOVEMNT DUE TO ACTUVATING WHAT

  • EPITHELIUM SODIUM CHANNEL
  • EPITHELIUM POTASSIUM CHANNEL
  • EPITHELIUM CALCIUM CHANNEL

4. WHAT IS THERE ALSO AN IMBALANCE OF IN ADDITION TO TISSUE INJURY/TISSUE PROTECTION AND PROTEASE/ANTIPROTEASE?

  • OXIDANT/ANTIOXIDANT
  • C3b AND IgG
  • ANTIPROTEASE

5. what is the Barrier to phagocytes; inhibits complement and antibody binding

  • Exotoxin A
  • Mucoid exopolysaccharide (alginate)
  • Pyocyanin
  • Pseudomonas elastase
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