cystic fibrosis 10 The basic genetic defect in cystic fibrosis (CF) and the structure of CFTR

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1. CFTR consists of: select correct answer

  • CFTR consists of two transmembrane domains (TM1 and TM2), two nucleotide binding domains (NBD1 and NBD2), and a unique intracellular hydrophilic regulatory (R ) domain.
  • CFTR consists of three transmembrane domains (TM1, TM2, TM3), two nucleotide binding domains (NBD1 and NBD2), and a unique intracellular hydrophilic regulatory (R ) domain.
  • CFTR consists of two transmembrane domains (TM1 and TM2), three nucleotide binding domains (NBD1, NBD2 and NBD3), and a unique intracellular hydrophilic regulatory (R ) domain.
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2. WHICH CLASS OF CFTR MUTATIONS ARE Regulatory mutants which reach the surface of the cell, but do not respond normally to activation signals (G551D).

  • CLASS 5
  • CLASS 3
  • CLASS 4
  • CLASS 6

3. what chromosome is the CFTR gene on?

  • 7
  • 6
  • 14
  • 3

4. what else is found bound to Erin?

  • PKA
  • PKD
  • cAMP

5. The defect is in the gene coding for which chloride ion channel, which is expressed in all epithelial cells?

  • the cystic fibrosis transmembrane conductance regulator (CFTR),
  • the cystic fibrosis transmembrane conductance regulator (CFTCR),
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