Cushing's disease 0.0 / 5 ? MedicineEndocrinologyEndocrine disordersUniversityOther Created by: FarhanaAhmedCreated on: 07-01-17 21:22 Name 2 effects of cortisol Anti-inflammatory and gluconeogenesis 1 of 15 Name 4 clinical benefits of cortisol Organ transplantation, cerebral oedema, rheumatoid arthritis and Addison's disease 2 of 15 What are some adverse effects of excess glucocorticoids? Myopathia, glaucoma, diabetes, osteoporosis, Cushing's syndrome, infection-prone, loss of libido 3 of 15 What is the pathophysiology of excess corticotropin releasing hormone? Adrenal hypertrophy (enlarged adrenal glands) 4 of 15 Name the 3 hormones in order in the HPA axis of glucocorticoid production Corticotropin releasing hormone, adrenocorticotropic hormone, cortisol. 5 of 15 What is the disease when excess cortisol levels are seen in a patient? Cushing's disease 6 of 15 Which patients are at most risk of Cushing's disease? Female, 20-50 years old, type II diabetic 7 of 15 Which tests can determine if a patient suffers Cushing's syndrome? Dexamethosone test: detects if high levels of cortisol in the night 8 of 15 What are exogenous and endogenous Cushing's syndrome? Exogenous is due to long-term/high-dose use of cortisol and endogenous is due to a tumour in one of the glands. 9 of 15 Which 4 ways can cortisol be administered in a patient? Oral, injection, inhalation and topical application 10 of 15 What is the long-term risk of excess, untreated cortisol in the body? Incidence of hypertension and cardiovascular diseases which can be fatal 11 of 15 How is exogenous Cushing's treated? GRADUALLY stop medication of cortisol - abrupt withdrawal can cause serious side effects 12 of 15 How is endogenous Cushing's treated? Surgery to remove tumour otherwise cortisol-suppressing drugs given 13 of 15 What are the symptoms of Cushing's disease? Moon face, skin thinning, rashes, abdominal fat, hypertension, buffalo hump, muscle wastage, osteoporosis. 14 of 15 What happens if after endogenous Cushing's surgery, the patient suffers low level of cortisol? Undergo cortisone replacement therapy 15 of 15
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