Pituitary Disease

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  • Created by: Becca
  • Created on: 24-12-13 16:16
When are dynamic stimulation tests done? How do they diagnose pituitary disease?
Hyposecretion suspected e.g. secondary hypthyroidism. TRH normally stimulates TSH. Failure to stimulate TSH/T4 indicates hormone insufficiency in TSH
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When are dynamic suppression tests done? How do they diagnose pituitary disease?
Hypersecretion suspected e.g. acromegaly (GH tumour). Oral glucose tolerance test - high plasma glucose conc normally supresses GH release. Failure to suppress GH secretion indicates autonomous secretion (GH tumour)
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How is pituitary disease managed?
Pharmacological management, surgery (craniotomy or trans-sphenoidal) & radiotherapy - potential side effects of hypopituitarism and damage to optic pathways
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Name 4 specific pituitary diseases.
Hyperprolactinaemia, Acromegaly, Cushing's syndrome & Hypopituitarism
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What causes hyperprolactinaemia? Symptoms? Treatment?
Cause: prolatinoma, damage to pituitary stalk. Symptoms: loss of fertility/libido, galactorrhoea, gynaecomastia. Treatment: dopamine receptor agonists (inhibit prolatin secretion & shrink tumour), surgery/radiotherapy (drug resistant tumours)
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What causes acromegaly? Symptoms? Treatment?
Cause: excessive GH in adults (children = gigantism). Symptoms: coarsening of facial features, enlarged hands/feet. Treatment: surgical removal of tumour, radiotherapy, somatostatin analogues & dopamine receptor agonists (inhibit GH release)
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What causes Cushing's syndrome? What is the treatment?
Cause: ACTH-secreting ant pituitary tumour (= Cushing's disease), excessive glucocorticoid activity, endo/exogenous (steroid medication). Treatment: tumour removal (radiotherapy for residual disease)
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What is hypopituitarism? Causes? Treatment?
Deficiency of one or more pituitary hormones, pan-hypopituitarism = deficiency of all pituitary hormones. Caused by pituitary adenoma, surgery/radiotherapy/severe head trauma damages pituitary stalk. Treatment: hormone replacement
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Card 2

Front

When are dynamic suppression tests done? How do they diagnose pituitary disease?

Back

Hypersecretion suspected e.g. acromegaly (GH tumour). Oral glucose tolerance test - high plasma glucose conc normally supresses GH release. Failure to suppress GH secretion indicates autonomous secretion (GH tumour)

Card 3

Front

How is pituitary disease managed?

Back

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Card 4

Front

Name 4 specific pituitary diseases.

Back

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Card 5

Front

What causes hyperprolactinaemia? Symptoms? Treatment?

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