BMS1031 Molecular Biology 0.0 / 5 ? Biologymolecular biology UniversityAll boards Created by: tammyrocks4evaCreated on: 22-04-14 10:40 Transcription defines the process where by: DNA is converted to RNA 1 of 38 DNA is made of which substrates? Phosphate, pentose sugar and organic bases 2 of 38 Which Bases are NOT pyrimidines? Adenine and Guanine 3 of 38 A nucleoside = Sugar and base 4 of 38 Phosphodiester bonds form in which direction? 5' to 3' 5 of 38 DNA replication is? semi conservative 6 of 38 Which statement about DNA polymerase is incorrect? Moves in a 3' to 5' direction 7 of 38 How is the 3' to 5' strand get synthesised? The lagging strand is copied as short fragments which are joined using DNA ligase 8 of 38 What is the role of topoisomerase during DNA replication? Relieves twists in DNA ahead to prevent super coiling, by creating a nick ahead of the replication fork 9 of 38 What is the role of tRNA? Decodes mRNA for protein synthesis, bringing the correct amino acid to the end of the protein 10 of 38 Which RNAs have regulatory roles? miRNA and siRNA 11 of 38 what are cajal bodies? Non-membrane bound nuclear substructures that act in RNP biogenesis and the modification of snRNA and snoRNA 12 of 38 which RNAs make up eukaryotic ribosomes? 28S, 18S, 5.8S, 5S 13 of 38 Which statement is incorrect about tRNA? are very large proteins >100 nts 14 of 38 Where does the promotor region lie on DNA? Upstream if start site 15 of 38 RNA polymerase II transcribes which RNAs? mRNA, miRNA, siRNA, snoRNA, snRNA 16 of 38 what are the next two stages of transcription called? Elongation and termination 17 of 38 UTRs are? Retained in mRNA but untranslated 18 of 38 pre-mRNA splicing involves? 2 sequential phosphoryl-transfer reactions to join exons 19 of 38 What are the benefits of pre-mRNA splicing? A and B 20 of 38 Which proteins are NOT used for mRNA export from the nucleus? eIF4G 21 of 38 The insertion or deletion of nucleotides that disrupt the reading frame are: Frameshift mutations 22 of 38 Which molecules are not involved in translation activation? RNA polymerase 23 of 38 eIF4 and eIF4g are involved during translation initiation by? allowing sm.ribosomal subunit to recognise and bind mRNA 24 of 38 Bacterial mRNA is often polycistronic, meaning? Several proteins can be encoded from the same mRNA 25 of 38 How does the ribosome help form peptide bonds between amino acids? A and C 26 of 38 How does rifamycin work? blocks initiation of RNA chains by binding to RNA polymerase 27 of 38 Which proteins aid in the co-translational protein folding? Heat shock proteins 28 of 38 Peptide bonds do NOT exhibit which quality? Are very weak and easily broken with low energy reactions 29 of 38 Secondary structures are held together by which bonds? Hydrogen, electrostatic and van der waals 30 of 38 Which statement about alpha helixes is incorrect? Results from H-bonding between every other AA 31 of 38 Which secondary structure can either be parallel or antiparallel? Beta pleated sheets 32 of 38 Globular domains tend to: Be found in catalytic and signalling proteins 33 of 38 What is a protein domain? An independently folded region with characteristic properties 34 of 38 Small molecules, ions or macromolecules that form weak bonds to binding sites are: Ligands 35 of 38 Which enzyme cleaves polysaccharide chains in bacterial cell walls in hydrolysis reactions? Lysozyme 36 of 38 Cofactors are: Vitamins and minerals thats associate with active sites of an enzyme to increase reactivity 37 of 38 Which regulation process is incorrect? control of folding 3' and 4' structures 38 of 38
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