BIOLOGICAL THERAPY FOR SCHIZOPHRENIA

BIOLOGICAL THERAPY FOR SCHIZOPHRENIA

A01

TYPICAL ANTIPSYCHOTICS.

DOPAMINE ANTAGONISTS:

-since 1950's

-act as antagonists in the dopamine system and aim to reduce dopamine.

-block dopamine receptors in the synapses in the brain.

-dopamine levels build up after taking CHLORPROMAZINE, then production is reduced.

-This normalises neurotransmission in the brain reduces hallucinations.

-Chlorpromazine also has a sedation (relaxing) effect as it has an effect on histamine receptors.

ATYPICAL ANTIPSYCHOTICS.

CLOZAPINE:

-Binds to dopamine receptors and acts on glutamate and serotinin receptors.

-reduces depression and anxiety, improves cognitive functioning and mood.

…