Scientific Method

• What variables do you need to measure to test your hypothesis 
• What are your test subjects (limitations, ethical implications, must be matched) 
• Intervals of measurement (equal, appropriate for study) 
• pre/post intervention (what data are u getting before and after intervention)  
• Case-control  
• Multiple measurement modalities to eradicate any other factors e.g. white coat hypertension 
• “Proof of concept”- want to go back around the loop to show that you have actually answered the question proposed.  

Limitations to scientific progress 

• The technology isn't available 
• The statistics don't work out 
• Human error 

Before you start an experiment: 

• Decide what you are going to do 
• The number and frequency of observations 
• Familiarisation with the technology 
• Take additional measurments 
• Consistency and completeness of the observations 
• Record any deviations from the proposed protocol