Other slides in this set

Slide 2

Preview of page 2

Here's a taster:

Parkinson's is a
neurodegenerative
disorder. Say that three
times fast!
How it occurs
Involves the loss of nerve cells in the
substantia nigra.
Dopamine is a neurotransmitter. It has
axons which spread through the frontal
cortex, the brain stem and the spinal
cord.
Dopamine-producing cells die and motor
control is gradually lost.
Symptoms usually begin to show after
80% of these cells are gone.…read more

Slide 3

Preview of page 3

Here's a taster:

Back to The Future star
Michael J. Fox was
diagnosed with Parkinson's
when he was just 30 years
old!
Development
It usually develops in people over 50 years old,
but it can appear in younger people (very
rare).
The causes are still not clear.
In young-onset Parkinson's there is a relatively
strong genetic link.
In common Parkinson's the genetic link is
much weaker ­ other factors may also be
involved.…read more

Slide 4

Preview of page 4

Here's a taster:

Symptoms
Tremor (shaking) of the muscles
Slow movements
Stiff muscles
Poor balance
Walking problems
Depression
Breathing and speech problems
Swallowing difficulty
Sleeping problems…read more

Slide 5

Preview of page 5

Here's a taster:

Sadly, There is
NO CURE for
Parkinson's.
Treatments
Levodopa (L-dopa): a precursor of dopamine
which can cross the blood brain barrier and
be converted into dopamine
Dopamine agonists: they bind to dopamine
receptors in brain synapses and mimic the
effect of dopamine
MAOB inhibitors: inhibits the enzyme MAOB,
which breaks down dopamine in the brain
synapse…read more

Slide 6

Preview of page 6

Here's a taster:

Gene therapy
Two approaches:
Adding genes to prevent the dopamine-
producing cells of the midbrain from dying
Adding genes to enhance the levels of
dopamine production in the remaining cells.
Some positive results, BUT there are major
problems in delivering the healthy genes to
the cells of the midbrain.…read more

Slide 7

Preview of page 7
Preview of page 7

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all resources »