Slides in this set
What is Parkinson's disease?
Parkinson's is a progressive
disease of the nervous system
marked by tremor, muscular
rigidity, and slow, imprecise
movement, affecting mostly the
middle-aged and elderly.
It is associated with a deficiency
of the neurotransmitter
dopamine due to a destruction
of the neurones that control
movement, adversely affecting
a person's motor skills.…read more
Dopamine is a neurotransmitter
used in body movement.
Loss of neurons results in a lack
of dopamine causing a decrease
in the transmission of the nerve
impulses involved in movement,
resulting in stiff and abnormal
Norepinephrine is a chemical Dopamine
closely related to dopamine. It is
the main chemical messenger of
the sympathetic nervous system
which controls many automatic
functions of the body such as
heart rate and blood pressure.
Parkinson's results in a loss of
both norepinephrine and nerve
endings that produce it.
This can explain the non-
movement features of Parkinson's
such as fatigue and irregular blood
Causes and risk factors
Genetics Environment Mitochondria
In rare cases Parkinson's Some researchers think Recent evidence
disease can run in that exposure to toxins suggests that mutations
families. could be the trigger. in genes linked to
In this situation abnormal Possible toxins include: Parkinson's results in
genes are responsible, pesticides and mitochondria dysfunction.
but the exact role herbicides used in Mitochondria are major
genetics plays in causing farming sources of free radicals
ordinary Parkinson's toxins released by which are molecules that
disease is unclear. industrial plants damage membranes,
proteins and DNA. This
air pollution related to damage is called
road traffic oxidative stress, causing
changes in brain cells.…read more