- Necrosis and apoptosis are both types of cell death, which follows the failure of a cell to adapt to injury
- They are both characterised by profound membrane and mitochrondrial dysfunction
- In both apoptosis and necrosis, the remnants of the cells are phagocytosed
- Necrosis is always pathological whereas apoptosis can be induced pathologically or physiologically
- Necrosis affects groups of cells whereas apoptosis is the death of an individual cell although it can occur in multiple cells
- Apoptosis is energy-dependent whereas necrosis results from an energy failure
- In necrosis, there is a loss of membrane integrity. In apoptosis, the cell membrane remains intact.
- In apoptosis, the cell shrinks and fragments to form apoptotic bodies with dense chromatin. In necrosis, the cell swells and cell lysis occurs.
- There is no inflammatory response in apoptosis. However, necrosis induces inflammation.