Cell death: Necrosis and Apoptosis


	Cell death: Necrosis and Apoptosis
	Similarities Necrosis and apoptosis are both types of cell death, which follows the failure of a cell to adapt to injury They are both characterised by profound membrane and mitochrondrial dysfunction In both apoptosis and necrosis, the remnants of the cells are phagocytosed	Differences Necrosis is always pathological whereas apoptosis can be induced pathologically or physiologically Necrosis affects groups of cells whereas apoptosis is the death of an individual cell although it can occur in multiple cells Apoptosis is energy-dependent whereas necrosis results from an energy failure In necrosis, there is a loss of membrane integrity. In apoptosis, the cell membrane remains intact. In apoptosis, the cell shrinks and fragments to form apoptotic bodies with dense chromatin. In necrosis, the cell swells and cell lysis occurs. There is no inflammatory response in apoptosis. However, necrosis induces inflammation.
	Overall comparison

Necrosis and apoptosis are both types of cell death, which follows the failure of a cell to adapt to injury
They are both characterised by profound membrane and mitochrondrial dysfunction
In both apoptosis and necrosis, the remnants of the cells are phagocytosed

Necrosis is always pathological whereas apoptosis can be induced pathologically or physiologically
Necrosis affects groups of cells whereas apoptosis is the death of an individual cell although it can occur in multiple cells
Apoptosis is energy-dependent whereas necrosis results from an energy failure
In necrosis, there is a loss of membrane integrity. In apoptosis, the cell membrane remains intact.
In apoptosis, the cell shrinks and fragments to form apoptotic bodies with dense chromatin. In necrosis, the cell swells and cell lysis occurs.
There is no inflammatory response in apoptosis. However, necrosis induces inflammation.

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