The Dopamine Hypothesis
- Created by: Zoe Whiteman
- Created on: 19-04-16 18:00
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- The Dopamine Hypothesis
- A01
- Excess dopamine in brain= schizo symptoms
- Increased activity at dopamine synapses= paranoia
- Hallucinations occur as brain is too active
- Excess D2 receptors= key role in guiding attention
- Stimulation of the mesolimbic pathway= linked to positive symptoms
- Problems with dopamine functioning in the pathway connecting the midbrain to the frontal lobes= linked to negative symptoms
- Large doses of dopamine often found in the limbic system
- Lack of neurotransmitter glutamate= schizo symptoms
- A02
- Iverson- post mortems, high dopamine levels in schizos
- Lindstroem et al- PET scan, 10 schizos, 10 healthy controls, L-Dopa injected into brain, schizos took L-Dopa up quickly as more dopamine being produced
- Randrup + Munkvad- amphetamines to rats= increases schizo symptoms
- Barlow + Durand- chlorpromazine reduce schizo symptoms in 60% of cases
- Anti-schizo drugs cause Parkinson's symptoms= caused by lack of dopamine
- Excess dopamine may be as a result of schizo not a cause
- Drugs reduce sudden positive symptoms but not symptoms that come on slowly/negative symptoms= not full explanation
- A01
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