Regulation of Insulin Levels

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  • Regulation of insulin levels
    • Insulin is released by beta cells in the islets of Langerhans in the pancreas
    • Insulin secretion needs to be stopped if blood glucose gets too low
  • Insulin reduces the blood glucose concentration
    • Regulation of insulin levels
      • Insulin is released by beta cells in the islets of Langerhans in the pancreas
      • Insulin secretion needs to be stopped if blood glucose gets too low
  • Potassium ion channels are normally open allowing potassium ions to flow out
    • Glucose moves into the cell when blood glucose concentration levels are high
      • Glucose is metabolised to produce ATP
        • Production of ATP closes the potassium ion channels in the cell membrane
          • The inside of the cell becomes less negative because of the increase in potassium ions
            • As the potential difference changes calcium ion channels in the membrane, which are normally shut, open
              • Calcium ions allow vesicles of insulin to be released via the membrane by exocytosis
  • Calcium ions allow vesicles of insulin to be released via the membrane by exocytosis

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