P35
- Created by: fatmar:))
- Created on: 29-01-22 18:45
View mindmap
- P53
- What does it do?
- TP53 genes provide the instructutions to make a P53 protein - it's a phosphoprotein
- The protein is a tumour suppressor so it regulates cell division by inhibiting growth and cell division at a fast or uncontrolled rate
- Cell division is halted at the G1 and G2 phases of the cell cycle. (This is true for most Rb proteins as they block entry to the S phase)
- Fact; The P53 protein contains 393 amino acids
- In a normal cell, it has 3 roles ; growth arrest, DNA repair or apoptosis (cell death)
- The P35 gene is found on the 17th chromosome
- What types of cancer can it lead to?
- Breast cancer, lung cancer, brain cancer, bladder cancer and liver cancer
- LFS (Li-Fraumeni syndrome) is a genteically inheridented genetic syndrome where you have a higher risk of developing cancer.
- P35 gene mutations cause about 70% of LSF conditions
- It's dominant so only one copy of the mutated gene is needed
- Those affected often get diagnosed with cancer at an early age and many have multiple cancers
- How does it lead to the cancers?
- The protein is altered so it can't trigger apoptosis (death) of cells with damaged DNA
- Cells with the damaged DNA then undergo uncontrolled division or growth which leads to the formation of tumours
- The TP35 gene mutations change a single amino acid which then alters the base produced and impacts the function of the gene.
- The protein is altered so it can't trigger apoptosis (death) of cells with damaged DNA
- What can cause mutations?
- Usually it's caused by environmental factors such as ultraviolet light and tobacco smoke. The actual toxin is not known
- What does it do?
Comments
No comments have yet been made