nigostriatal pathway + huntingtons disease
- Created by: lw121x
- Created on: 10-12-15 20:01
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- nigostriatal pathway
- NORMALLY pathway from substansia nigra up to the ventral tomentum
- critical role in understanding Parkinson's
- The NS pathway displayed with thick arrow = massive influence on striatrium
- Motor cortex also exciting striatrum
- all this excitation inhibits the bsal ganglia bibus pilidus - if arrow thin = not inhibiting thalamus
- if thalamus isn't inhibited released from inhibition
- PARKINSONS, substantia nigra little influence on the striatum
- striatum not inhibiting basal ganglia now basal inhibits thalamus a lot thus doesn't help with the motor cortex
- symptoms hard to get excited motor cortex
- dopamine is a dopamine agonist replaces dopamine
- Pallidotomy - destroy globus pallidus release thalamus from inhibition
- Deep brain stimulation electrode change activity
- Huntingtons disease
- genetically transmitted
- abnormal movements
- chorea involutentary movement face neck limbs
- athetsis slow writing
- NORMALLY pathway from substansia nigra up to the ventral tomentum
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