degeneration of Da neurons connecting substantia nigra with striatum of BG (nigrostriatal pathway) -abnormal accumulation of alphasynuclein in Da cells (lewy bodies)
dengeneration of BG nuclei (caudate nucleus and putamen) -inhibitory GABAergic neurons in BG are affected -inherited-mutation of gene on chromos 4-protein it produces(huntingtin) is abnormal
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