Intrinsic and Extrinsic proteins

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  • membrane component
    • Extrinsic protein
      • Amino acids on surface of protein are hydrophilic
        • To interact with the hydrophilic phosphate heads in the bilayer
      • Transport of molecules across a membrane
      • Spans one layer of phospholipid bilayer or associated to one of the surfaces of the bilayer
      • Outside of the layer
    • Intrinsic protein
      • Spans both layers of the phospholipid bilayer
      • Amino acids on surface of the protein are hydrophobic
        • To interact with the hydrophobic fatty acids tails in the bilayer
      • Makes membrane selectively permeable
      • Transport proteins
      • Channel proteins
        • Hydrophilic channel allows movement of charged and polar molecules by diffusion
      • Carrier proteins
        • Move molecules by diffusion and active transport but the protein has to change shape to allow this

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