Enzyme models

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  • Enzyme models
    • Lock and key
      • enzyme and substrate = fully complimentary
      • Active site doesn't change shape
      • bonding is weaker
      • E.g. Amylase
      • proposed by Emil Fischer
    • Induced fit
      • Not fully complimentary
      • active site changes shape to bind with substrate
      • bonding is stronger
      • e.g. lysozyme (tears)
      • proposed by Daniel. E. Koshland

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