Models of Enzyme Action
- Created by: iloverevision:)
- Created on: 01-03-19 19:32
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- Models of Enzyme Action
- Lock & Key Model
- suggests substrate combines with enzyme at active site in precise way
- like the way lock & key fit
- active site always exact complementary shape (at optimum temperature) so reactions are fastest in these conditions
- following the reaction the products do not fit active site so escape leaving enzyme unaltered & free to react with more substrate
- 1 limitation of model is that enzyme is considered rigid structure
- scientists have observed that structure is not rigid
- structure is flexible
- scientists have observed that structure is not rigid
- suggests substrate combines with enzyme at active site in precise way
- Induced Fit Model
- suggests that substrate & active site are not exactly complementary to begin with
- when substrate binds with enzyme it induces changes in enzyme structure
- amino acids that make up enzyme's active site are moulded in to precise formation to wrap round substrate
- form enzyme-substrate complex
- active site changes shape to become complementary
- strained fit between active site & so reduces activation energy needed to break bond
- explains how binding of other molecules can affect enzymes' shape & activity
- provides explanation for how activation energy is lowered
- suggests that substrate & active site are not exactly complementary to begin with
- Lock & Key Model
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