CVD (1)

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  • CVD
    • Atheroma formation usually triggers CVD
    • Arteries are made of several layers, including endothelial lining which is smooth and unbroken
      • Damage to the endothelial layer triggers  inflammatory response.
        • Damage can be caused by high blood pressure
          • Endothelial damage means the layer cant function normally
        • The inflammatory response involves white blood cells moving into the area
          • White blood cells and lipids from the blood clump together under endothelial layer, forms fatty streaks
            • Over time, more white blood cells, lipids, connective tissue build up, harden and form plaque; an Artheroma
              • Plaque semi-blocks lumen, of artery and restricts blood flow
                • Blood pressure increases
                  • Hardening arteries caused by Atheroma, is called Atherosclerosis
    • Atheromas can increase the risk of a Thrombosis
      • Atheromas can burst through the endothelium of an artery, damages wall and surface is left rough
        • This causes a thrombosis to form at the site of damage
          • Blood clot can block the artery fully, or become dislodged
            • Blood flow to tissue is blocked, less oxygen to tissues
              • Can result in Heart attacks, Strokes and deep vein thrombosis (Forms of CVD)

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