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  • cardiovascular disease
    • lifestyle factors
      • Diet
        • saturated increases atheroma formation
        • salt increases blood pressure
      • high blood pressure
      • smoking
        • carbon monoxide binds to haemoglobin, reducing the amount of oxygen transported around the blood.
          • can lead to stroke, heart attack
        • nicotine makes platelets sticky,increasing blood clots,increasing risk of CVD.
        • reduces the amount of antioxidants in the blood, more cell damage, more atheromas.
      • inactivity(sedentary lifestyle)
    • factors beyond control
      • genetics
        • some people inherit particular alleles that make them more likely to have high bp/blood cholesterol.
      • age
        • plaque builds up over time
      • gender
        • men are 3x more likely-women have more oestrogen, increases levels of HDL.
    • treatment of CVD
      • antihypertensives (lower blood pressure)
        • diuretics
          • increase volume of urine, reducing blood volume and pressure.
        • calcium channel blockers
          • lower blood pressure-prevent ca from entering cells of heart +arteries-softer contractions,allow bv to relax +open.
        • ACE inhibitors
          • widen/dilate your bv,increases amount of blood your heart pumps and lowers bp, increases blood flow.
        • side effect/concern
          • palpitations,abnormal heart rhythms,fainting,headaches,drowsiness, bp too low,allergies,depression,low sodium levels.
      • lowering cholesterol
        • statins
          • reduces the amount of LDL produced in liver-reduces atheroma formation-inhibits enzyme.
        • muscle and joint pain,digestive system problems,increased risk of CVD
      • anti-coagulants(reduce blood clotting)
        • warfarin
          • prevent harmful blood clots from forming/growing any larger
            • severe bleeding,osteoporosis,fainting,allergies,swelling,damage to fetus if taken in pregnancy.
        • asprin
          • makes platelets less stick N.B(dual antiplatelet therapy)
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