Antithrombotics
- Created by: Mohsin
- Created on: 14-04-18 20:12
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- Antithrombotic
- reduces thrombus formation
- Anti-platelet
- Aspirin
- Clopidogrel
- Dipyridamole
- Anti-coagulant
- Warfarin
- MOA: inhibits the conversion of oxidised Vit K epoxide
- into reduced form - Vit K hydroquinone
- This inhibits Vit K dependant carboxylation
- of factors II, VII, IX and X
- metabolised by CYP2C9
- of factors II, VII, IX and X
- This inhibits Vit K dependant carboxylation
- into reduced form - Vit K hydroquinone
- MOA: inhibits the conversion of oxidised Vit K epoxide
- Heparin
- Sulphated glycosamino-glycans
- activate antithrombin III
- inactive factors I and X
- sub-cutaneous delivery
- immediate action
- un-fractionated or LMWH
- LMWH
- derived by depolymerisation of un-fractionated heparin
- results in various molecular weights
- differing ratio of inhibitory activity against Factor Xa or thrombin
- results in various molecular weights
- works by increasing antithrombin activity
- also releases tissue factor pathway inhibition
- has a greater capacity to potentiate factor Xa inhibition by antithrombin than thrombin
- because at least half of the LMWH chains are too short to bridge antithrombin to thrombin
- derived by depolymerisation of un-fractionated heparin
- LMWH
- Rivaroxaban
- Direct factor Xa inhibitors
- Warfarin
- Thrombolytic
- Streptokinase
- Tenecteplase
- Prothrombin time and INR
- PT = clotting time of citrated plasma after addition of Ca2+ and reference thrombo-plastin
- Patients prothrombin times is expressed as
- INR = (PT ratio)^ISI
- ISI = internation sensitivity index
- INR = (PT ratio)^ISI
- Patients prothrombin times is expressed as
- PT = clotting time of citrated plasma after addition of Ca2+ and reference thrombo-plastin
- Apixaban
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