Phase 1 drug metabolism 0.0 / 5 ? PharmacyPhase 1 drug metabolismUniversityNone Created by: StacyShiellsCreated on: 15-08-17 15:25 FMOs requires: NADPH+O2 1 of 20 Oxidises nucleophilic nitrogen, phosphorus and sulphur centres: FMO 2 of 20 Has both COX & Peroxidase activity? PHS 3 of 20 Metabolises nicotine? FMO1 4 of 20 Mitochondrial enzyme which oxidises in a FAD-dependent pathway? MAO 5 of 20 Metabolises neurotransmitters and propranolol? MAO-A 6 of 20 Requires NAD+ as a co-factor: Alcohol dehydrogenase 7 of 20 Plays a role in cyclophosphamide metabolism? Aldehyde dehydrogenase 8 of 20 Metabolises doxorubicin? Carbonyl reductase 9 of 20 Reduction reactions by? Carbonyl reductase & NQO1 10 of 20 Metabolises benzoquinone? NQO1 11 of 20 Hydrolysis reaction carried out by? esterase, epoxide hydrolases, 12 of 20 Esterase's and epoxide hydrolyses are found in the? cytosol and microsomes 13 of 20 Carboxylesterase 1 (hCE1) metabolises: cocaine & heroine 14 of 20 Butylcholinesterases (BChE) metabolise: aspirin 15 of 20 Carboxylesterase 2 (hCE2) metabolises: procaine 16 of 20 Paraoxonase (PON1) metabolises: aryl esters 17 of 20 Paraoxonase (PON3) activates: statins 18 of 20 Metabolise and active benzo[a]pyrene PON1 19 of 20 Enzymes which are synthesised in the liver and found in plasma, degrades oxidised lipids (protects LDL and HDL from lipideroxidation) PON1 (pon2,pon3) 20 of 20
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