CYP450 0.0 / 5 ? PharmacyCYP450UniversityNone Created by: StacyShiellsCreated on: 15-08-17 13:53 Most drugs are metabolised by which 3 CYP45Os? CYP2D6, CYP2C9, CYP3A4 1 of 21 Which CYP normally performs aromatic hydroxylation: CYP2D6 2 of 21 CYP2D6 substrates have? basic nitrogen, ionised at physiological pH, hydrophobic region 3 of 21 Which CYP can performs aromatic or aliphatic hydroxylation: CYP2C9 4 of 21 Which CYP normally performs N-dealkylation? CYP3A4 5 of 21 5-10% of the population lack the enzyme due to mutations? CYP2D6 6 of 21 Which CYP isoform is not induceable? CYP2D6 7 of 21 CYP2D6 substrates include: debrisoquine, amitriptyline, codeine 8 of 21 CYP2C9 substrates include: ibuprofen, s-warfarin, tienllic acid 9 of 21 CYP3A4 substrates include: verapamil, lidocaine, cyclosporin 10 of 21 CYP2C19 substrates include: omeprazole, clopidogrel 11 of 21 Which CYP isoform is subject to genetic polymorphism (low activity due to amino-acid substitutions) CYP2C9 12 of 21 CYP2C9 and CYP2C19 are both induced by? barbiturates and rifampicin 13 of 21 Rifampicin is both and inducer and a substrate for? CYP3A4 14 of 21 3% of the population lack enzyme activity due to a polymorphism: CYP2C19 15 of 21 CYP1A1 found outside the liver and induced by some of its substrates + involved in the activation of PAHs 16 of 21 CYP2E1 ethanol metabolism- autoinduction 17 of 21 CYP1A2 activates aryl amine compounds to carcinogens and metabolises caffeine 18 of 21 CYP4: fatty acid oxidation 19 of 21 CYP26: retinoid acid oxidation 20 of 21 CYP17: steroid biosynthesis (oestrogen) 21 of 21
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