CYP450

Most drugs are metabolised by which 3 CYP45Os?
CYP2D6, CYP2C9, CYP3A4
1 of 21
Which CYP normally performs aromatic hydroxylation:
CYP2D6
2 of 21
CYP2D6 substrates have?
basic nitrogen, ionised at physiological pH, hydrophobic region
3 of 21
Which CYP can performs aromatic or aliphatic hydroxylation:
CYP2C9
4 of 21
Which CYP normally performs N-dealkylation?
CYP3A4
5 of 21
5-10% of the population lack the enzyme due to mutations?
CYP2D6
6 of 21
Which CYP isoform is not induceable?
CYP2D6
7 of 21
CYP2D6 substrates include:
debrisoquine, amitriptyline, codeine
8 of 21
CYP2C9 substrates include:
ibuprofen, s-warfarin, tienllic acid
9 of 21
CYP3A4 substrates include:
verapamil, lidocaine, cyclosporin
10 of 21
CYP2C19 substrates include:
omeprazole, clopidogrel
11 of 21
Which CYP isoform is subject to genetic polymorphism (low activity due to amino-acid substitutions)
CYP2C9
12 of 21
CYP2C9 and CYP2C19 are both induced by?
barbiturates and rifampicin
13 of 21
Rifampicin is both and inducer and a substrate for?
CYP3A4
14 of 21
3% of the population lack enzyme activity due to a polymorphism:
CYP2C19
15 of 21
CYP1A1
found outside the liver and induced by some of its substrates + involved in the activation of PAHs
16 of 21
CYP2E1
ethanol metabolism- autoinduction
17 of 21
CYP1A2
activates aryl amine compounds to carcinogens and metabolises caffeine
18 of 21
CYP4:
fatty acid oxidation
19 of 21
CYP26:
retinoid acid oxidation
20 of 21
CYP17:
steroid biosynthesis (oestrogen)
21 of 21

Other cards in this set

Card 2

Front

Which CYP normally performs aromatic hydroxylation:

Back

CYP2D6

Card 3

Front

CYP2D6 substrates have?

Back

Preview of the front of card 3

Card 4

Front

Which CYP can performs aromatic or aliphatic hydroxylation:

Back

Preview of the front of card 4

Card 5

Front

Which CYP normally performs N-dealkylation?

Back

Preview of the front of card 5
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