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  • Adaptive immune system
    • Organ-specific and responds slowly on first presentation
    • Cells based in lymphoid tissue require interaction with antigen presenting cells
      • Macrophages, dendritic cells and B cells are all APCs
        • Dendritic cells bind antigen and move from peripheral to lymphoid tissue
        • APCs contain toll-like receptors (TLRs) on their surfaces
          • 10 TLRs identified in humans to date - each binds to specific molecular patterns
          • TLR activation results in cytokine production to mount an adaptive immune response
        • Specialised lymphocytes (B and T cells) contain antigen-specific receptors
          • Both B and T cells are produced in the bone marrow and can secrete and respond to cytokines


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