solubility

Created by: anna888
Created on: 20-02-23 17:24

describe 3 methods of meausring solubility

1. dissolution rate testing- dissoltion rate beaker apparatus, plot graph of conc vs time 2. equilibrium solubility test- excess solid added till saturated solution reached, time irrevant 3. intrinsic dissolution rate- linear regoin in graph, ficts law ac

1 of 9

describe equilibrium of dissolution

solid-aqueous via dissolution. aqueous- solid via precipiation. Ksp const

2 of 9

describe basis around solubility pH graphs

increased ionisation = increased solubility. ph=pka means 50% ionisation + for acids -for bases .

3 of 9

factors that cause supersaturation, what is the result

temp and pH changes, increases in precipiation to return to stable equilibrium postion

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why does volume increase in dissolution, effect on water activity?

hydration shells form around the solute. less free water means less water activity as the amount of solute increases

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basis of ficks 1st and 2nd law

1st- how fast does diffusion occur 2nd- how long does it take for a specific conc to be reached at a certain point

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explain bcs classification system

i=high perm high solu ii= high perm, low solu iii= low perm, high solu iv= low perm, low solu

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what is volume and ph in stomach- significance for bcs calcs

v=250ml pH =1-2. used to detremine if high solubility or not by x solubility by stomach volume and comparing ionisation and thus how solubility is effected when in stomach

8 of 9

what is good f, significance for bcs calcuations

equal/over 85%. if this then permability is high

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Other cards in this set

Card 2

Front

describe equilibrium of dissolution

Back

solid-aqueous via dissolution. aqueous- solid via precipiation. Ksp const

Card 3

Front

describe basis around solubility pH graphs

Back

Card 4

Front

factors that cause supersaturation, what is the result

Back

Card 5

Front

why does volume increase in dissolution, effect on water activity?

Back

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solubility