Sleep (Narcolepsy) 0.0 / 5 ? PsychologySleepA2/A-levelAQA Created by: SophieCreated on: 28-05-15 18:10 Who found that mice with lower levels of hypocretin were cataplexing? Yanagasiwa 1 of 10 What did Dement find? Narcoleptic mice weren't producing hypocretin 2 of 10 What did Mignot find? Narcoleptic dogs had a faulty gene associated with the production of hypocretin 3 of 10 Why did Mahouald and Schneek criticise these findings? Absence of hypocretin doesn't explain all cases of narcolepsy 4 of 10 What does HLA do? Controls the immune response to attack 5 of 10 What did Mignot believe? Narcolpetics have faulty HLA. The immune systems of narcoleptics attack their own bodies - targeting their own body cells. 6 of 10 How did Mignot test this? Gathered 1800 patients with faulty HLA - found that 800 of them were narcoleptics 7 of 10 Why do these findings suggest that faulty HLA is not enough to bring about narcolepsy? Concordance was not 100% - suggests environmental factors are needed for the disorder to develop 8 of 10 What evidence is there of a bacterial trigger for narcolepsy? Narcoleptics have significantly more antibodies for certain bacterias 9 of 10 What evidence is there of a vaccination trigger for narcolepsy? Following the 2010 swine flu vaccinations incidence of narcolepsy increased 17x 10 of 10
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