Sleep (Narcolepsy)

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  • Created by: Sophie
  • Created on: 28-05-15 18:10
Who found that mice with lower levels of hypocretin were cataplexing?
Yanagasiwa
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What did Dement find?
Narcoleptic mice weren't producing hypocretin
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What did Mignot find?
Narcoleptic dogs had a faulty gene associated with the production of hypocretin
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Why did Mahouald and Schneek criticise these findings?
Absence of hypocretin doesn't explain all cases of narcolepsy
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What does HLA do?
Controls the immune response to attack
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What did Mignot believe?
Narcolpetics have faulty HLA. The immune systems of narcoleptics attack their own bodies - targeting their own body cells.
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How did Mignot test this?
Gathered 1800 patients with faulty HLA - found that 800 of them were narcoleptics
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Why do these findings suggest that faulty HLA is not enough to bring about narcolepsy?
Concordance was not 100% - suggests environmental factors are needed for the disorder to develop
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What evidence is there of a bacterial trigger for narcolepsy?
Narcoleptics have significantly more antibodies for certain bacterias
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What evidence is there of a vaccination trigger for narcolepsy?
Following the 2010 swine flu vaccinations incidence of narcolepsy increased 17x
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Other cards in this set

Card 2

Front

What did Dement find?

Back

Narcoleptic mice weren't producing hypocretin

Card 3

Front

What did Mignot find?

Back

Preview of the front of card 3

Card 4

Front

Why did Mahouald and Schneek criticise these findings?

Back

Preview of the front of card 4

Card 5

Front

What does HLA do?

Back

Preview of the front of card 5
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