S2W5 Heart failure as a drug target DH

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What is the definiton of heart failure?
An inability of the heart to pump blood around the body effectively.
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What happens when you have right sided heart failure?
Fluid build up in the body - oedema- typically in the legs.
Peripheral oedema which may be pitting.
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What happens when you have left sided heart failure?
Fluid build up - oedema - in lungs
Pulmonary oedema
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What is congestive cardiac failure?
Failure of both sides of the heart
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What are the most important investigations for heart failure?
BNP (brain natriuretic peptide)
Echocardiogram
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Why is BNP a good investigation for heart failure?
BNP is a good indication for heart failure as it is only released from cardiomyocytes in response to stretch or strain, so it tells us if the heart is over exerting itself (increased ventricular blood volume)
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What is ejection fraction?
How well blood is pumped out the left ventricle with each beat.
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What is Heart failure with reduced ejection fraction (HFrEF)?
The heart muscle is not able to contract adaquately and therefore expels less oxygen-rich blood.
Affects more men than women
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What is Heart failure with preserved ejection fraction (HFpEF)?
Heart muscles contract normally but thickened mucle causes the ventricles to hold an abnormally small volume of blood.
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What are the symptoms of left sided heart failure?
Breathlessness, lying flat cough with pink sputum, tiredness, lightheadness and fainting
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What are the symptoms of right sided heart failure?
Heavy painful legs, difficulty walking, skin infections, tiredness, lightheadness and fainting
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What are the key causes of heart failure?
Hypertension
Ischaemic heart disease
Valve disease
Cardiomyopathy
Arrythmia
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What is preload?
The amount of stretch on the heart muscle after diastole - the amount of blood in the ventricle.
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How is preload reduced?
Loop diuretics .i.e furosemide act on NKCC in ascending limb of LOH
Aldosterone antagonists .i.e spironolactone, decrease Na reabsorption
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What is afterload?
The amount of pressure the heart has to pump against - blood pressure in the aorta
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How do you reduce afterload?
Antihypertensives - ACE inhibitors .i.e Ramipril and calcium channel blockers .i.e amlodipine
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What is rate control of the heart?
lowing the heart down to improve ejection fraction
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How do you reduce heart rate?
B1 adrenergic recpetor antagonists (Beta blockers) .i.e bisoprolol
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Other cards in this set

Card 2

Front

What happens when you have right sided heart failure?

Back

Fluid build up in the body - oedema- typically in the legs.
Peripheral oedema which may be pitting.

Card 3

Front

What happens when you have left sided heart failure?

Back

Preview of the front of card 3

Card 4

Front

What is congestive cardiac failure?

Back

Preview of the front of card 4

Card 5

Front

What are the most important investigations for heart failure?

Back

Preview of the front of card 5
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