S1W15 Introduction to Biopharmaceuticals (PD)

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Created by: Tino Muronda
Created on: 25-03-21 09:52

What are biopharmaceuticals?

Any pharmaceutical drug product derived in, extracted from or synthesised from a biological source

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What are some examples of biopharmaceuticals?

Insulin
Human growth hormone
Adalimumab
Omalizumab

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What is an example of the pfoduction method of biopharmaceuticals?

Human insulin gene is combined with bacterial plasmid
This forms a recombinant plasmid
Bacterial transformation and heterologous expression occurs
Then we get protein purification and the formation of a biologic

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What are the advantages and disadvantages of this method?

Adv: High yield
Dis: May contain endotoxins
Post translational processing may differ compared to mammalian cells

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What are some alternative expression systems?

Chinese hamster ovary cells
Plants
Transgenic cattle

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What are some differences between biopharmaceuticals and conventional drugs?

Biopharmaceuticals are usually bigger
Most biopharmaceuticals are unique but conventional are easy to synthesise identical batches.
conventional drugs usually have a predictable relationship between dose and effect.
Conventional drugs are often oral admin

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What is gene therapy?

A strategy to deliver a functioning copy of a detective gene to a target cell using a suitable vector

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What are suitable vectors for gene therapy?

Liposomes
DNA casettes
Herpes simplex virus type I
Adenovirus
Retrovirus

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Other cards in this set

Card 2

Front

What are some examples of biopharmaceuticals?

Back

Insulin
Human growth hormone
Adalimumab
Omalizumab

Card 3

Front

What is an example of the pfoduction method of biopharmaceuticals?

Back

Card 4

Front

What are the advantages and disadvantages of this method?

Back

Card 5

Front

What are some alternative expression systems?

Back

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S1W15 Introduction to Biopharmaceuticals (PD)