Respiration

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Where does respiration occur?
In all living organisms cells; animals, plants, fungi, yeast, bacteria, protoctists etc.
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What is the purpose of respiration?
Releases chemical protential energy in organic molecules (fats, carbs, proteins etc)
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What happens to this energy?
Used to synthesise ATP (from ADP + Pi) and ATP hydrolysing it; releasing energy needed to drive biological processes
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For what biological processes do organisms need energy for?
Active transport, exocytosis, endocytosis, synthesis of macromolecules, DNA replication, activation of chemicals, cell division + movement
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Anagram for this?
An elephant eats slugs daily and can't move
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What are chemical reactions collectively known as?
Metabolic reactions
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Types of metabolic reactions?
Anaphoric (making large molecules from smaller ones) + cataphoric (hydrolysis of large molecules into smaller ones)
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Purpose of the rest of energy released from respiration + the hydrolysis of ATP?
Heat energy- used to keep the organism warm so enzyme-catalysed reactions occur at/near their optimum
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What is ATP?
A phosphorylated nucleotide: adenine, ribose sugar + 2 phosphate group (phosphoryl group)
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ATP is relatively stable in cells, what does this mean?
It doesn't break down in ADP and Pi; so won't affect the water potential of cells
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What enzyme readily breaks down ATP?
Catalysis
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What happens when ATP is hydrolysed?
It releases a small quantity of energy, that's managable for cells to do work
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The benefit of a small quantity of energy released?
Doesn't cause damage in cells
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Why is ATP the universal energy currency?
It's used in all living cells as a source of energy
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What is glycolysis?
The conversion of glucose to pyruvate
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Where does it occur?
In the cytoplasm
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What are the 3 stages of glycolysis?
1) phosphorylation of glucose 2) splitting of hexose biphosphate 3) oxidation of triose phosphate
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What enzyme oxidises triose phosphate, aided by what?
Dehydrogenase, aided by coenzyme NAD
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Purpose of NAD?
Accepts the electrons + protons (H atoms) from TP becoming reduced in the process
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What makes NAD and NADP different?
They are structurally different (due to the phosphate group in NADP), so work with different enzymes
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The net product of glycolysis?
2 reduced NAD + 4ATP + 2 molecules of pyruvate
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What does reduced NAD do?
Carries the electrons + protons (H) to the cristae for oxidative phosphorylation
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When it gives up the electrons + protons what happens?
It becomes reoxidised so can oxidise more substrate TP in glycolysis
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What happens to pyruvate produced in glycolysis?
It is transported through a specific pyruvate-H+ symport across the mitochondrial envelope into the matrix
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What is the link reaction?
The dehydrogenation and decarboxylation of pyruvate by a larger multi-enzyme complex called pyruvate dehydrogenase
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What is dehydrogenase and decarboxylation?
The removal of carboxyl (COO) and (H)
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What does this leave behind?
An acetyl group
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In the process what happens to NAD?
It is reduced
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What happens to the acetyl group?
It combines with coenzyme A, to from acetylCoA
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Why?
It prevents anything else from binding with the carbon group, before the krebs cycle
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What does coenzyme A do?
Carries acetyl to the krebs cycle in the form of acetylCoA
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Word equation for the link reaction?
2 pyruvate + 2NAD + 2CoA --> 2acetylCoA + 2NAD + 2Co2
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Why 2 molecules of pyruvate?
As 2 molecules of pyruvate are produced in glycolysis
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Card 2

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Releases chemical protential energy in organic molecules (fats, carbs, proteins etc)

Card 3

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Card 4

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Card 5

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Anagram for this?

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