receptor theories

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  • Created by: anna888
  • Created on: 28-01-23 18:03
describe ehrlichs side chain theory
cell activation via ligand interaction with receptor
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describe the occupation theory
drug effect is directly proport to no. of receptors occupied
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describe lock and key concept
substrate has specific and complemtary shape to active site of enzyme. if shape wrong, no reaction occurs
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describe rate theory
response is proport to the rate of assos and dissos of the complex. agonist has fast assos and dissos. antagonist has fast assos but slow dissos.
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describe induced fit theory
mutual moulding ofboth ligand and receptor to give best fit. conformational changes in dynami process
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describe macromolecular perturbation theory
agonist has specific conformational perturbation resulting in a response. antagonist has non specific and no response
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describe the activation-aggregation theory
drug receptor is in equib between active and inactive state. agonist binds to active while antagonist binds to innactive
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describe the two state receptor model
regardless of ligand presense, drug receptor exisits in equib between r and r* state. agonist has high affinity for r* state, reverse agonist has high affinity for r state while an antagonist has equal affinity for both states
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Card 2

Front

describe the occupation theory

Back

drug effect is directly proport to no. of receptors occupied

Card 3

Front

describe lock and key concept

Back

Preview of the front of card 3

Card 4

Front

describe rate theory

Back

Preview of the front of card 4

Card 5

Front

describe induced fit theory

Back

Preview of the front of card 5
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