Female reproductive physiology

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  • Created by: ez
  • Created on: 03-05-14 13:01
Where are the GnRH nuclei found?
Preoptic Area
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What kind of GnRH release is seen in males?
Tonic only
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What effect do GABAnergic neurones have on GnRH neurones?
Inhibits them
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What effect does Beta Endorphin have?
Inhibits LH
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What effect does Noradrenaline have on GnRH neurones?
Stimulates them
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What effect does dopamine have on GnRH neurones?
Inhibits them
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What effect does progesterone have on GnRH release?
Inhibits it
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What does FSH do?
Stimulates follicular growth in ovaries
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What does LH do?
Triggers ovulation and corpus luteum development
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Which oestradiol receptors do GnRh neurones express?
ER beta
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What form of feedback on GnRH release is mediated by Kisspeptin neurones?
Positive and negative feedback
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What is added in glycosylation of the Beta subunits of gonadotrophins?
Carbohydrates and sialic acid
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What type of receptor is the GnRH receptor?
G-coupled protein receptor
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What happens to FSH levels after ovulation?
They fall
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What does inhibin do?
Inhibits FSH
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What does activin do?
Promotes FSH
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What does follistatin do?
Binds to and inhibits activin
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What do low-frequency GnRH pulses do?
Stimulate release of FSH
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What is the dominant hormone in the follicular phase?
Oestrogen
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What produces oestradiol in the follicular phase?
The dominant follicle
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What state are gametes arrested in at birth of the female animal?
Primary oocyte
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What is produced at first oestrus (i.e. puberty onset)?
Secondary oocyte and polar body
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Are primary oocytes...
Diploid?
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Are secondary oocytes...
Haploid?
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What type of epithelium do the granulosa cells of a primary follicle form?
Stratified cuboidal
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What is required before a tertiary follicle can develop?
LH surge
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At what point does oestradiol synthesis by the follicle begin?
Secondary follicle
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Which follicular cells does FSH stimulate?
Granulosa cells
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What does a regressed corpus luteum form?
Corpus albicans
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What induces luteolysis?
Uterine hormones
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What stimulates the production of prostaglandin F2a?
Oxytocin from corpus luteum
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What triggers puberty?
Decrease in the sensitivity of the hypothalamus to oestradiol
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What accompanies the gonadostat theory?
Change in tone of neurones acting on GnRH neurones
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What is FSH highly sensitive to?
Negative feedback of oestradiol
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Other cards in this set

Card 2

Front

What kind of GnRH release is seen in males?

Back

Tonic only

Card 3

Front

What effect do GABAnergic neurones have on GnRH neurones?

Back

Preview of the front of card 3

Card 4

Front

What effect does Beta Endorphin have?

Back

Preview of the front of card 4

Card 5

Front

What effect does Noradrenaline have on GnRH neurones?

Back

Preview of the front of card 5
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