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6. Inactivation of isoniazid by NAT2 is related to?
- slow acetylator
- fast acetylator
- intermediate acetylator
- extensive acetylator
7. Enzyme which consists of 2 subunits of a MW approx. 34,000:
8. Why are so few xenobiotics conjugated?
- Salicylic CoA is selective
- MACS is selective
- Acyl-CoA:glycine N-acetyltranserase is selective
- both enzymes involved are selective
9. SULT found at highest levels in the liver:
- SULT1C2
- SULT1C4
- SULT1A1
- SULT1A3
10. amino-acid conjugation is found where in the cell?
- cytoplasm
- microsomes
- mitochondria
- ER
11. GSTs conjugate the reduced glutathione (GSH) to?
- electrophillic compounds
- neucleophillic compounds
- electric compounds
- electrostatic compounds
12. Sulfation use what as a source of sulphate:
13. Which classes of GSTs are inducible?
- Alpha & Mu
- Alpha & Theta
- Alpha & Pi
- Mu & Theta
14. acetyltransferases used what to donate an acetyl group?
- UDP-glucuronic acid
- PAPs
- acetyl coenzyme A
- MACs
15. NAT drug substrates require a:
- alcohol-group
- amino-group
- amine-group
- hydroxyl-group
16. UGT1:
- 10 isoforms, products of the same gene
- isoforms are not gene encoded
- isoforms are products of separate genes
- isoforms have chromosomal variation
17. The association with NAT2 and bladder cancer is due to inactivation of?
- arylamine dyes
- isoniazid
- phenobarbitone
- PhlP
18. GSTs are found in the majority of tissue and are found at what concentration in human liver?
19. NAT1 + NAT2 are located where in the cell?
- mitochondria
- microsomes
- cytosol
- ER
20. GSH reacts through:
- electrophilic thiamine thiol group
- electrophilic cysteine thiol group
- neuclophillic cysteine thiol group
- neuclophillic sulphur thiol group