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6. Inactivation of isoniazid by NAT2 is related to?

  • slow acetylator
  • fast acetylator
  • intermediate acetylator
  • extensive acetylator

7. Enzyme which consists of 2 subunits of a MW approx. 34,000:

  • SULTs
  • UDP-GTs
  • GSTs
  • NATs

8. Why are so few xenobiotics conjugated?

  • Salicylic CoA is selective
  • MACS is selective
  • Acyl-CoA:glycine N-acetyltranserase is selective
  • both enzymes involved are selective

9. SULT found at highest levels in the liver:

  • SULT1C2
  • SULT1C4
  • SULT1A1
  • SULT1A3

10. amino-acid conjugation is found where in the cell?

  • cytoplasm
  • microsomes
  • mitochondria
  • ER

11. GSTs conjugate the reduced glutathione (GSH) to?

  • electrophillic compounds
  • neucleophillic compounds
  • electric compounds
  • electrostatic compounds

12. Sulfation use what as a source of sulphate:

  • MACS
  • SAM
  • PAPS
  • NAD+

13. Which classes of GSTs are inducible?

  • Alpha & Mu
  • Alpha & Theta
  • Alpha & Pi
  • Mu & Theta

14. acetyltransferases used what to donate an acetyl group?

  • UDP-glucuronic acid
  • PAPs
  • acetyl coenzyme A
  • MACs

15. NAT drug substrates require a:

  • alcohol-group
  • amino-group
  • amine-group
  • hydroxyl-group

16. UGT1:

  • 10 isoforms, products of the same gene
  • isoforms are not gene encoded
  • isoforms are products of separate genes
  • isoforms have chromosomal variation

17. The association with NAT2 and bladder cancer is due to inactivation of?

  • arylamine dyes
  • isoniazid
  • phenobarbitone
  • PhlP

18. GSTs are found in the majority of tissue and are found at what concentration in human liver?

  • 1000mM
  • 10mM
  • 100mM
  • 1mM

19. NAT1 + NAT2 are located where in the cell?

  • mitochondria
  • microsomes
  • cytosol
  • ER

20. GSH reacts through:

  • electrophilic thiamine thiol group
  • electrophilic cysteine thiol group
  • neuclophillic cysteine thiol group
  • neuclophillic sulphur thiol group