pharmacogenetics 0.0 / 5 ? BiologypharmacogeneticsUniversityNone Created by: anna888Created on: 06-02-23 16:47 define pharmacogenetics study of genetic basis of differing drug responses in an indidual 1 of 10 define pharmacogenomics study of the genes in the genome that influence drug effects and metabolism 2 of 10 what is a polymorphisms, give two examples genetic variations ocuring in more than 1% of an ethnically diverse population. snp and strs 3 of 10 PK vs PD polymorphism effects Pk= changes drug metabolism. pd =changes drug target 4 of 10 what is p450 that has most effect on metabolism if polymorphism CYP450 2D6 5 of 10 describe effects of ultra rapid vs poor metaboliser if given same drug ultra fast means theraputic window too short so drug not effective. if poor, drug not broken down so can have toxic effects. 6 of 10 explain prodrugs and metabolism polymorphisms prodrugs must be metabolised to active form to be effective. poor metabolisers wont convert prodrug to active form so wont work 7 of 10 why should we use personalised medicines (3) 1.reduce side effects/allergic effects 2. improve effectiveness 3. prevent adr's 8 of 10 three drugs with pharmacogenetic implications azathioprine,codeine,warafin 9 of 10 three ethical implications of pharmacogenetics privacy issues, should insurer have acess to info, does patient have right to know of future illness likehood in genome 10 of 10
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