Test which determines if the gelatin is good enough to be used in capsules. The resistance of the gelatin gel to a probe is measured - 250g for hardshell capsules and 150g for soft shell capsules
Bloom strength
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Gelatin obtained from swine skins
Type A
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Gelatin prepared by treating bone and tissue with hydrochloric acid to dissolve the calcium compounds
Type B
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The formation of strong chemical linkages beyond simple hydrogen and ionic bonds between gelatin chains
Cross linking
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Enzyme which can overcome the effects of mild to moderate cross-linking within the body
Pepsin
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Enzyme which can overcome the effects of mild to moderate cross-linking within the body
Pancreatin
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Which substance can decompose to form formaldehyde, which can lead to cross-linking with a gelatin capsule shell?
Corn starch
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An alternative shell material to gelatin which is of a vegetarian source, opaque, similar dissolution profile and water content (12-14%) to gelatin
Potato starch
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An alternative shell material to gelatin which is of a vegetal source, has a slower disintegration rate and a lower moisture content (2-6%)
HPMC
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An alternative shell material to gelatin which is of a vegetarian source, has a similar disintegration, dissolution, moisture content and transparency as gelatin, and has a good barrier to oxygen
Pullulan
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A lightly compressed powder that can be used to fill capsules
Plug
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An industrial scale capsule filling system which produces 15-25000 capsules/hr. The capsule body passes under hopper on a turntable and the system rotates at a constant speed. Fill weight is dependent on speed of rotation
Auger system
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An industrial capsule filling system where powder falls into small cavities on a dosing plate which is then tamped by a pin to form a plug. The dose is controlled by the thickness of the powder and the degree of tamping. The plug is then ejected
Piston tamp
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An industrial capsule filling system where a stainless steel cylinder with a spring loaded piston is lowered into a powder bed. The powder is forced up into the cylinder to form a plug. The plug is then released into the capsule shell
Dosator
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A method of capsule sealing where a roller applies a solution to the cap-body intersection
Banding
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A method of capsule sealing where sealing fluid is applied to the cap-body intersection and the air is heated to 40-60 degrees to seal the two parts
Liquid spray
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A method of capsule sealing where a vibrating sonoprobe is applied to a thermoplastic interface which provides localised frictional heat to produce a molecular bond at the interface
Sonic welding
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This is a capsule which has a tablet within a capsule or a capsule within a capsule
Overencapsulation
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These excipients make soft-gel capsule shells flexible and elastic which are added to the shell formulation before drying. Examples: Glycerin, sorbitol, propylene glycol
Plasticiser
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This type of capsule has its shell made out of gelatin powder mixed with water, glycerin and a colouring
Soft gel
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Does oxygen permeability increase or decrease with humidity and glycerol content
Decrease
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This type of capsule uses a fill temperature of 70 degrees and has a more effective barrier to water, light and oxygen
Hard shell
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This type of capsule uses a fill temperature of 35 degrees and has a less effective barrier to water, light and oxygen
Soft gel
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Other cards in this set
Card 2
Front
Gelatin obtained from swine skins
Back
Type A
Card 3
Front
Gelatin prepared by treating bone and tissue with hydrochloric acid to dissolve the calcium compounds
Back
Card 4
Front
The formation of strong chemical linkages beyond simple hydrogen and ionic bonds between gelatin chains
Back
Card 5
Front
Enzyme which can overcome the effects of mild to moderate cross-linking within the body
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