introduction to dosage forms 0.0 / 5 ? Pharmacyintroduction to dosage formsUniversityNone Created by: RscottqubCreated on: 04-03-19 21:52 why do we need dosage forms? accurate dosing. mask taste. protection . 1 of 16 protection from? gastric juice. moisture. 2 of 16 A formulation consists API (active pharmaceutical ingredient)+ exipients 3 of 16 advantages of solid dosage forms much more stable compared to liquid dosage forms. easy storage, transport. accurate dosage 4 of 16 Disadvantages solid dosage form often complex and expensive equipment is required 5 of 16 tablets are compressed powder 6 of 16 capsules are made from gelatin 7 of 16 types of capsules hard shell- 2 piece system, solid inside. soft shell- 1 piece system- liquid filled 8 of 16 advantages of tablets/capsules more stable Vs Liquid DFs. accurate dosage . easy handling, manufacture and storage 9 of 16 disadvantages of tablets/capsules too slow in emergency. some ppl have difficulty swallowing. some drugs resist compression into tablets 10 of 16 2 stages for drug to be absorbed into blood dissolution + absorption - a drug cannot be absorbed unless it is dissolved in solution 11 of 16 enteric coated tablets coated in polymer which only breaks down in pH>5 ie in the intestine 12 of 16 disintegrants an exipient which swells in water to help break the tablet up - increase dissolution rate 13 of 16 lubricant prevent powder sticking to machinery 14 of 16 why is granulation required? powders do no flow well leading to an non-uniform . granules are larger particles and will flow better 15 of 16 granulation process mix dry masses of drug+ exipients. Add aq binder to produce a wet mass. Sieve to produce granules. Dry granules. add lube 16 of 16
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