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What factors affect distribution?

What does distribution of lipophilic drugs depend on?

Hydrophilic and large drugs have limited distribution. Why?

Which tissues have a high perfusion rate and which have a slow?

What is redistribution?

Describe the redistribution of I.V anaesthestic(temp loss of sensation)

Porous capillaries allow?

Why must drugs be lipophilic to diffuse into the brain?

What does P-Glycoprotein (transporter) do?

How does L-Dopa get into the CNS?