Molecules of life

  • Created by: SamDavies
  • Created on: 22-04-19 16:41
The name of the polymer of nucleotides
Nucleic acid
1 of 49
This structure is made up of a heterocyclic base, a pentose sugar and a phosphate group
Nucleotide
2 of 49
This structure is made up of a heterocyclic base and a pentose sugar
Nucleoside
3 of 49
The name of the linkage which attaches the phosphate group to a nucleotide on its 5' or 3' end
Phosphodiester
4 of 49
Name of the group of cytosines, thymine and uracil
Pyrimidines
5 of 49
Structure of pyrimidines
Monocyclic
6 of 49
Name of the group of adenines and guanines
Purines
7 of 49
Structure of purines
Bicyclic
8 of 49
The name of the linkage which attaches the heterocyclic base to the pentose sugar at carbon 1
N-glycosidic
9 of 49
The number of hydrogen bonds between adenine and thymine
Two
10 of 49
The number of hydrogen bonds between cytosine and guanine
Three
11 of 49
The number of amino acids considered 'essential', i.e. they must come from diet as the body cannot synthesise them.
Nine
12 of 49
The name of one of the two amino acids that are not naturally found in DNA
Cystine
13 of 49
The name of one of the two amino acids that are not naturally found in DNA
Hydroxyproline
14 of 49
The name of the only amino acid that does not have a chiral centre and so does not exist as a mixture of two enantiomers
Glycine
15 of 49
The configuration of all naturally occurring amino acids - L or D?
L
16 of 49
The name of the only amino acid that gives an R configuration instead of S
Cysteine
17 of 49
The type of amino acid in which both the amine and the carboxylic group are attached to the same carbon
Alpha
18 of 49
The type of amino acid in which the amine and the carboxylic acid group are found on different carbon atoms (not very common)
Beta
19 of 49
The pKa of SP2 amines
Five
20 of 49
The pKa of SP3 amines
Ten
21 of 49
The pKa of carboxylic acids
Five
22 of 49
The pKa of phenols
Ten
23 of 49
The pKa of alcohols
Fifteen
24 of 49
The two groups which are ionised at physiological pH
SP3 amines and carboxylic acids
25 of 49
The primary reason why some amino acids have acidic/basic groups which are more/less basic than others
Electron withdrawing groups
26 of 49
The name given to the pH at which a zwitterion carries no net charge
Isoelectric point
27 of 49
The name of the type of amino acid synthesis in which the reagents are an aldehyde, NH3 and HCN
Strecker
28 of 49
The reagents needed for the hydrolysis stage in Strecker synthesis of amino acids
H3O+, H2O, heat
29 of 49
The substance required to react with a carboxylic acid in order to produce an acyl chloride
Thionyl chloride
30 of 49
A common example of a carbodiimide activates carboxylic acids in situ
DCC
31 of 49
This protecting group can be removed by reacting with HBr in acetic acid
Cbz
32 of 49
This protecting group can be removed by reacting with HCl or CF3COOH in acetic acid
Boc
33 of 49
This protecting group can be removed by reacting with piperidine
Fmoc
34 of 49
The molecule involved in automated peptide synthesis
Insoluble resin
35 of 49
The acid used to remove the solid resin at the end of automated peptide synthesis
HBr in CF3COOH
36 of 49
The amino acid formed when two peptide fragments are brought together in native chemical ligation
Cysteine
37 of 49
The name of the reagent used to cleave off the last amino acid in a peptide so that it can be identified by standard analytical chemistry. This technique is known as Edman degradation
Phenyl isothiocyanate
38 of 49
One of the protease enzymes involved in cleaving a peptide sequence in order to determine the sequence of amino acids
Chemotrypsin
39 of 49
A molecule which can reduce a disulfide bond back into two cysteine amino acids
DTT
40 of 49
The phenomenon that is limited due to resonance shown in all amino acids (due to the amide group)
Degree of freedom
41 of 49
The configuration which is energetically favoured in amino acids
Trans
42 of 49
A flat network of two peptide sequences which hydrogen bond to each other. They can be parallel and anti-parallel
Beta sheets
43 of 49
The type of beta-pleated sheet which has stronger H bonds because the H bonds are in straight lines between the two chains
Anti-parallel
44 of 49
The bending of a long peptide chain
Beta turn
45 of 49
The amino acid which introduces a 'kink' in polypeptide chains
Proline
46 of 49
A right handed ordered coil of a polypeptide chain which is stabilised by H bonding
Alpha helices
47 of 49
The type of H bonding network in an alpha helices
Vertical
48 of 49
The second type of kinase inhibitor with the first being ATP-competitive kinase inhibitors
Allosteric inhibitor
49 of 49

Other cards in this set

Card 2

Front

This structure is made up of a heterocyclic base, a pentose sugar and a phosphate group

Back

Nucleotide

Card 3

Front

This structure is made up of a heterocyclic base and a pentose sugar

Back

Preview of the front of card 3

Card 4

Front

The name of the linkage which attaches the phosphate group to a nucleotide on its 5' or 3' end

Back

Preview of the front of card 4

Card 5

Front

Name of the group of cytosines, thymine and uracil

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Pharmacy resources:

See all Pharmacy resources »See all Molecules of Life resources »