R = Oral
D.R = 20-60mg daily, single or divided doses
1 of 6
Fluoxetine:
Indications? Cautions?
I = Major depressive disorder, bulimia, OCD, menopausal symptoms
C = poorly controlled epilepsy -> manic phase, history of bleeding disorders, cardiac disease
2 of 6
Fluoxetine:
Side effects? Toxicity?
S.E = chills, uterine disorder, vasodilation, blurred vision, post menopausal haemorrhage
T = tremor, convulsions, sinus tachycardia
3 of 6
Fluoxetine:
Mechanism of Action?
M.o.A = selective serotonin reuptake inhibitor,
inhibits the presynaptic reuptake of serotonin
4 of 6
Fluoxetine:
Absorption? Distribution?
A = < 90% oral bioavailability via hepatic 1st pass metabolism
D = 94% plasma protein bound + lipophilic -> to brain. vol. 20-42 L/kg (fluoxetine + norfluoxetine)
5 of 6
Fluoxetine:
Metabolism? Elimination?
M = -> norfluoxetine by cp450 enzymes. fluoxetine + norfluoxetine facilitate excretion via glucuronidation. Hippuric acid is created (N-demethylation + O-dealkylation)
E = primarily via urine
6 of 6
Other cards in this set
Card 2
Front
Fluoxetine:
Indications? Cautions?
Back
I = Major depressive disorder, bulimia, OCD, menopausal symptoms
C = poorly controlled epilepsy -> manic phase, history of bleeding disorders, cardiac disease
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