LECURE 3 RENAL FUNCTIONS TESTS AND ALGORITHMS 0.0 / 5 ? BiologyRENAL FUNCTIONS TESTS AND ALGORITHMSUniversityOther Created by: LailaFrancisCreated on: 11-02-23 23:09 why measure GFR? identifying & diagnosing renal disease, monitoring disease progression 1 of 13 Renal clearance definition (ml/min) volume of plasma from which all trace of a substance is removed per unit time 2 of 13 2 substances representing in renal clearance by kidneys inulin and creatinine 3 of 13 what is inulin inert, dietary polysaccharide 4 of 13 what is creatinine breakdown product of muscle creatine 5 of 13 how is renal plasma flow (RPF) measured by determining the renal clearance of p-aminohippuric acid (PAH). 6 of 13 properties of a substance used to measure GFR freely filtered by glomerulus, not secreted or reabsorbed by tubules, and not metabolised 7 of 13 the substance must not what? not influence what’s being measured 8 of 13 properties of substance to measure RPF actively secreted and not reabsorbed by tubules, not metabolised 9 of 13 what can be used as a substitute for renal clearence measurements GFR algorithms 10 of 13 2 most well known GFR algorithms Cockcroft-Gault (CG) formula and the Modification of Diet in Renal Disease (MDRD) Study formula 11 of 13 what are GFR algorithms dependent on finding a stable plasma creatinine value 12 of 13 why can these GFR algorithms be problematic? variable plasma creatinine levels e.g muscle gain 13 of 13
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