clinically important proteins

?
what does caeruloplasmin indicate?
wilson's disease = autosomal recessive disorder where copper is deposited in the brain, liver and eye
1 of 32
what does transferrin indicate?
inflammation - decreased in inflammation due to excessive degradation of the protein
2 of 32
what does albumin indicate?
Oedema = decreased protein leads to interstitial fluid leaking into surrounding tissue. if raised could be due to dehydration
3 of 32
what does amylase indicate?
pancreatitis = released from damaged tissue and excreted in urine
4 of 32
what does alanine aminotransferase indicate?
liver disease, fatty liver, hepatitis, and paracetamol overdose
5 of 32
what does creatine kinase indicate?
skeletal and cardiac muscle damage
6 of 32
what does alkaline phosphatase indicate?
liver disease = present in cells in bilary duct
7 of 32
what does C-reactive protein indicate?
acute phase responce to tissue injury = clinically monitor infection and its treatment
8 of 32
what is false about urine albumin creatinine ratio (ACR)?
increased microalbumin is usually due to leakage in late glomerular damage
9 of 32
which statement is false about bence-jones protein?
measured by protein electrophoresis and light absorbtion
10 of 32
what does a grey topped tube do?
containes fluoride to stop glucose metabolism by RBCs = diabetes
11 of 32
what can not cause insulin excess (diagnosed by measuring proinsulin, insulin, and c-peptide)?
diabetes mellitus
12 of 32
what is not a symptom of hypothyroidism?
high T4 and T3
13 of 32
what is not a symptom of hyperthyroidism?
constipation
14 of 32
what is not a symptom of addison's disease (primary adrenal insufficiency)
high sodium and low potassium
15 of 32
what is not a symptom of cushing's syndrome (excess cortisol)?
hypotension
16 of 32
what is false about excess growth hormone?
giantism in adults and children
17 of 32
what is false about growth hormone deficiency?
only in adults
18 of 32
what is not a symptom of hyperprolactinaemia (raised level of prolactin in the blood)?
contraction in uterus
19 of 32
what is not a test or a treatment of hyperprolactinaemia
biopsy of uterine lining
20 of 32
what is not a function of PO4?
low energy phosphates (ATP, GTP)
21 of 32
what is false about bone formation?
osteoblasts reabsorb bone to release Ca, PO4, and degredated collagen
22 of 32
what is false about calcium economy in the kidney?
susceptible to damage by low levels of calcium and precipitation which causes reduction in ability to concentrate urine and polyuria
23 of 32
what is not a function of Vitamin D?
goes to liver then hypothalamus where it has an exocrine function
24 of 32
what is false about the parathyroid hormone receptor (PTHr)
primary stimulates ammonia secretion
25 of 32
what is not a symptom of hypocalcaemia?
kidney failure
26 of 32
what is not a cause of hypocalcaemia?
parathyroid adenoma (benign) without normal feedback control
27 of 32
what is not a broad group inborn errors of metabolism?
renal dysfunction with hyperdysfunction
28 of 32
what is not a feature of secondary accumulation of toxins
rare in neonates
29 of 32
what is not a feature of energy deprivation?
long symptom-free interval - can occur in older children after periods of prolonged fasting
30 of 32
what is not a feature of liver dysfunction/hypoglycaemia?
treatment of galactosaemia = increase galactose
31 of 32
what is not a feature of dysmorphism?
very high activity of alpha - L-iduronidase in skin fibroblasts
32 of 32

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Card 2

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what does transferrin indicate?

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inflammation - decreased in inflammation due to excessive degradation of the protein

Card 3

Front

what does albumin indicate?

Back

Preview of the front of card 3

Card 4

Front

what does amylase indicate?

Back

Preview of the front of card 4

Card 5

Front

what does alanine aminotransferase indicate?

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