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1. Renal clearance definition (ml/min)
- volume of plasma from which all trace of a substance is removed per unit time
- volume of nephrons from which all trace of a substance is removed per unit time;
- volume of urine from which all trace of a substance is removed per unit time;
- volume of bile from which all trace of a substance is removed per unit time;
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2. properties of substance to measure RPF
- actively secreted and not reabsorbed by tubules, not metabolised
- actively secreted and reabsorbed by tubules, not metabolised
- not secreted and not reabsorbed by tubules, not metabolised
- not secreted and reabsorbed by tubules, not metabolised
3. 2 most well known GFR algorithms
- Cockcroft-Gault (CG) formula and the Modification of Diet in Renal Disease (MDRD) Study formula
- Cockcroft-Ganff(CG) formula and the Modification of Diet in Renal Disease (MDRD) Study formula
4. why can these GFR algorithms be problematic?
- variable plasma creatinine levels e.g muscle gain
- variable plasma inulin levels e.g muscle gain
5. what can be used as a substitute for renal clearence measurements
- GFR algorithms
- RPF algorithms
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