Lecture 6 0.0 / 5 ? PsychologyPsychobioUniversityAll boards Created by: adamedwardsCreated on: 22-08-18 20:49 How many receptors does dopamine have and are they inotropic or metbotropic? 5, metabotropic 1 of 16 Where is dopamine found and where does it project to? Found in SN and VTA and project to striatum, PFC and limbic system 2 of 16 What is basal ganglia responsible for? (5) Motor, cognition, motivation, emotions and mood 3 of 16 What is in the dorsal and ventral striatum? Dorsal = caudate nucleus and putamen and ventral = nucleus accumbens 4 of 16 Where do dopamine neurons degenerate in Parkinson's? Substantia Nigra 5 of 16 How are the direct and indirect pathways involved in Parkinson's? Impoverished movements along the direct pathway and indirect pathway becomes more active resulting in unwanted movements 6 of 16 What neurotransmitter can help in Parkinson's and why? L-Dopa, it can penetrate the blood barrier 7 of 16 What is the danger of persistent L-Dopa? Tolerance 8 of 16 What pathways does dopamine get sent through from the VTA? mesocortical pathway to dorsal striatum (PFC), mesolimbic pathway to ventral (Nucleus accumbens) 9 of 16 What types of scz are there? Schziaffective disorder, schziphreniform disorder, brief psychotic disorder and delusional disorder 10 of 16 What is associated with good recovery of scz? Treatment early, identifiable trigger, more positive symptoms, good social support, employment, no family history 11 of 16 What are some aetiological causes of scz? Genes, low SES, family criticism, substance abuse, amphetamines, cannabis 12 of 16 What neurological substrates are linked to scz? Enlarged ventricles, brain volume reduction 13 of 16 What is the dopamine hypothesis of scz? Positive symptoms results from excess dopaminergic transmission, hypersensitivity, inc amount of receptors 14 of 16 What dopamine antagonist affects d2 receptors? Chlorpromazine 15 of 16 What are some issues with chlorpromazine? Only affects positive symptoms and can result in parkinson's symptoms 16 of 16
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