Lecture 6

How many receptors does dopamine have and are they inotropic or metbotropic?
5, metabotropic
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Where is dopamine found and where does it project to?
Found in SN and VTA and project to striatum, PFC and limbic system
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What is basal ganglia responsible for? (5)
Motor, cognition, motivation, emotions and mood
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What is in the dorsal and ventral striatum?
Dorsal = caudate nucleus and putamen and ventral = nucleus accumbens
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Where do dopamine neurons degenerate in Parkinson's?
Substantia Nigra
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How are the direct and indirect pathways involved in Parkinson's?
Impoverished movements along the direct pathway and indirect pathway becomes more active resulting in unwanted movements
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What neurotransmitter can help in Parkinson's and why?
L-Dopa, it can penetrate the blood barrier
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What is the danger of persistent L-Dopa?
Tolerance
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What pathways does dopamine get sent through from the VTA?
mesocortical pathway to dorsal striatum (PFC), mesolimbic pathway to ventral (Nucleus accumbens)
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What types of scz are there?
Schziaffective disorder, schziphreniform disorder, brief psychotic disorder and delusional disorder
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What is associated with good recovery of scz?
Treatment early, identifiable trigger, more positive symptoms, good social support, employment, no family history
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What are some aetiological causes of scz?
Genes, low SES, family criticism, substance abuse, amphetamines, cannabis
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What neurological substrates are linked to scz?
Enlarged ventricles, brain volume reduction
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What is the dopamine hypothesis of scz?
Positive symptoms results from excess dopaminergic transmission, hypersensitivity, inc amount of receptors
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What dopamine antagonist affects d2 receptors?
Chlorpromazine
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What are some issues with chlorpromazine?
Only affects positive symptoms and can result in parkinson's symptoms
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Card 2

Front

Where is dopamine found and where does it project to?

Back

Found in SN and VTA and project to striatum, PFC and limbic system

Card 3

Front

What is basal ganglia responsible for? (5)

Back

Preview of the front of card 3

Card 4

Front

What is in the dorsal and ventral striatum?

Back

Preview of the front of card 4

Card 5

Front

Where do dopamine neurons degenerate in Parkinson's?

Back

Preview of the front of card 5
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