Kidney drugs 0.0 / 5 ? ChemistryPharmacologyUniversityAll boards Created by: sophieridgeCreated on: 15-05-18 18:54 What are diuretics? Drugs that increase excretion of salt and water by the kidneys. They reduce Na+ and Cl- reabsorption in the nephron 1 of 9 What are diuretics used for? oedematous conditions, heart failure, renal disease and hepatic disease. hypertension 2 of 9 Jv=? net flux of water across the vascular wall directly proportional to osmotic and pressure gradients 3 of 9 Where do diuretics act on nephron 1. PT. 2,Loop-prevent Na+ K+ Cl- entering cells in thick ascending limb. 3,Thiazide-blocks Na+, Cl- co-transport in the distal convoluted tubule, reduce plasma volume, venous return, CO. 4 of 9 continued. 4.Collecting tubule-inhibit Na+ uptake and K+ secretion prevents hypokalaemia. amiloride-sodium channel 5 of 9 K= sparing diuretics act to inhibit Na+ reabsorption and K+ secretion. Aldosterone receptor antagonist and blockers of epithelial NA+ channel. 6 of 9 Spironolactone example of K+ in collecting tube acting on aldosteronereceptor 7 of 9 ENaC blcokers block collecting t Na+ channel and K+sparing diuretics 8 of 9 Thiazide/loop diuretics Increase delivery of Na+ and fluid to CT. increases NA+ uptake and secretion of K+ and H+ 9 of 9
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