Kidney drugs

What are diuretics?
Drugs that increase excretion of salt and water by the kidneys. They reduce Na+ and Cl- reabsorption in the nephron
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What are diuretics used for?
oedematous conditions, heart failure, renal disease and hepatic disease. hypertension
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Jv=?
net flux of water across the vascular wall directly proportional to osmotic and pressure gradients
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Where do diuretics act on nephron
1. PT. 2,Loop-prevent Na+ K+ Cl- entering cells in thick ascending limb. 3,Thiazide-blocks Na+, Cl- co-transport in the distal convoluted tubule, reduce plasma volume, venous return, CO.
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continued.
4.Collecting tubule-inhibit Na+ uptake and K+ secretion prevents hypokalaemia. amiloride-sodium channel
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K= sparing diuretics
act to inhibit Na+ reabsorption and K+ secretion. Aldosterone receptor antagonist and blockers of epithelial NA+ channel.
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Spironolactone
example of K+ in collecting tube acting on aldosteronereceptor
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ENaC blcokers
block collecting t Na+ channel and K+sparing diuretics
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Thiazide/loop diuretics
Increase delivery of Na+ and fluid to CT. increases NA+ uptake and secretion of K+ and H+
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Card 2

Front

What are diuretics used for?

Back

oedematous conditions, heart failure, renal disease and hepatic disease. hypertension

Card 3

Front

Jv=?

Back

Preview of the front of card 3

Card 4

Front

Where do diuretics act on nephron

Back

Preview of the front of card 4

Card 5

Front

continued.

Back

Preview of the front of card 5
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