Cause vasoconstriction, they are 5-HT1a serotonin agonists that also inhibit inflammatory mediators, stop release of Substance P, stop n&v
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How can drugs reach the brain during migraine attack?
Due to vasodilation and inflammation, BBB is broken so it allows drug act directly on the brain
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How do ergotamines work in migraine?
stop inflammatiob, cause vasoconstriction, used second-line if triptans are ineffective
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What antiemetics are available?
domperidone, metoclopramide, cyclizine
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What NSAIDs are recommended for migraine?
diclofenac, paracetamol, aspirin, ibuprofen
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Is sumatriptan a first-line treatment?
No, NSAIDs and antiemetics are recommended first.
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What prophylaxis is available for migraine and what does it aimto achieve?
Decrease severity and frequency of headaches and increase acute treatment response. Beta-blockers, TCAs, valproate, pizotifen (serotonin agonist & histamin antagonist)
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What complications can develop with migraine?
clots and cardiocascular complication. patients should avoid COC
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What are the red flags for migraine?
severe headache not resolving in 5 days, extremely fast onset (no prodrone stage), very young or very old age, postural changes, red eyes due to burst blood vessels
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Other cards in this set
Card 2
Front
What else can cause head pain?
Back
Nerve compression, traction, inflammation, increased intracranial pressure, irritation of the meninges
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