The study of the distribution of diseases in populations and of factors that influence the occurrence of disease
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What is genetic epidemiology
The study of the joint action of genes and environmental factors that influence the occurrence of disease and their patterns of inheritance in families
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What is Descriptive Epidemiology?
Describing the disease and noticing that the DNA Genotype contributes to the DNA Phenotype as well as prevalence from different populations
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what is familial aggregation?
understanding the clustering of different traits within a given family
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What did heritability studies show?
Showed that genes and the environment play a part in the disease or trait a person has
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What did segregation analyses do
estimated the genetic model of a disease by looking at the multigenerational family data
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What is the correct order for the historical overview of gene discovery?
Is candidate gene studies hypotheses or not driven?
Hypothesis- driven
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What is candidate gene studies based on?
current understanding of biology and pathophysiology of the disease
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Categorical and Quantitative are examples of what?
Outcomes
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Exposure is to do with genetic variation (copy number) true or false
True
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Design's like cohort and case-control are for what type of design
Observational
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What does SNP Stand for?
Single Nucleotide Polymorphisms
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0 copy is...
commom homozygote
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1 Copy is ....
Rare Homozygote
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2 copy is .....
Heterozygote
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If you did a quantitative trait cohort based analysis e.g. against BMi, what stats test would you do?
Linear Regression Analysis (P Value)
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If you were to do a case control status analysis e.g. disease and cut point what stats test would you do?
Logistic regression analysis (P value + odds value)
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What does this describe? 20,000-25,000 genes, used to identify the 3 billion base pairs of our genome, to store information for all public
Human Genome Project
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How many populations does the HapMap Project phase 2 include
4
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What does the HapMap Project show?
the genetic variations located within a particular gene
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The main advantage of the HatMap Project is that it takes into consideration LD, but what is complete LD?
When the genetic variations are inherited together
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It can only look at common variants not rare ones is a disadvantage of what project?
HapMap Project
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Co-founding is a disadvantage of candidate gene studies, but what is it?
when there is a third variable that affects exposure and disease outcomes and gives false findings e.g. ethnicity
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what can selection bias cause
population stratification
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When can you cause information bias?
Misclassification of exposure of disease
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Other cards in this set
Card 2
Front
What is genetic epidemiology
Back
The study of the joint action of genes and environmental factors that influence the occurrence of disease and their patterns of inheritance in families
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