formulation-solubility of drugs

HideShow resource information
why is hydrolysis important in formulation?
it affects the stability of the drugs. it is a common metabolic pathway for drugs with amide,ester...
1 of 11
describe the process of dissolution
-drug molecules break away from the solid structure. - a cavity is formed in the solvent structure for the accommodation of the drug. - the drug molecule locates with in the cavity becoming solvated
2 of 11
what are the factors affecting solubility
1) molecular weight 2) H-bonding 3) hydrophobic/hydrophillic 4) temperature
3 of 11
how can u improve a drugs solubility?
1) formation of salt 2) incorporation of water solubility groups 3) using special dosage forms
4 of 11
how does the formation of salt help with its solubility?
salts dissociate in water to form hydrated ions, low melting and oily material can be converted to crystalline solids (solid dossage forms, smaller particles can also be formed aiding dissolution.
5 of 11
what is the disadvantage to salt formation?
has a higher molecular weight, so the proportion of active ingredient is reduced due to solubilty so higher doses are required
6 of 11
what are the four things to consider when adding a water solubilising group?
1) type of group added 2) position of incorporation 3) reversible or irreversible 4) chemical route of introduction
7 of 11
The degree of ionisation can be determined by the henderson-hasselbalch equation. what is the equation?
pKa= pH +Log [unionised form] / [ionised form]
8 of 11
what are the special dosage forms?
-micelles= lipophobic drugs with poor water solubility, -mixed micelles= mixture of lipids to optimise delivery, -liposomes= lipophobic drugs via core lipophillic drugs via bilayer
9 of 11
what does the partition co-efficient measure?
the dispersion of a compound in a lipid base and aqueous base
10 of 11
what is the partition- co-efficient equation?
Log P= [unionised compound]octanol/ [unionised compound] water
11 of 11

Other cards in this set

Card 2

Front

describe the process of dissolution

Back

-drug molecules break away from the solid structure. - a cavity is formed in the solvent structure for the accommodation of the drug. - the drug molecule locates with in the cavity becoming solvated

Card 3

Front

what are the factors affecting solubility

Back

Preview of the front of card 3

Card 4

Front

how can u improve a drugs solubility?

Back

Preview of the front of card 4

Card 5

Front

how does the formation of salt help with its solubility?

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Chemistry resources:

See all Chemistry resources »See all formulation- solubility of drugs resources »