Factors affecting drug metabolism

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1. What happens to the Km and Vmax in reversible mixed inhibition?

  • Km increases, Vmax decreases
  • Km increases, Vmax increases
  • Km and Vmax stay the same
  • Km increases, Vmax stays the same
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Other questions in this quiz

2. Differences in expression patterns in rats are seen in?

  • CYP3A, CYP3B, CYP3C, CYP4A
  • CYP2A, CYP2B, CYP2C, CYP3A
  • CYP1A, CYP1B, CYP1C, CYP2A
  • CYP2A, CYP2B, CYP2C, CYP3B

3. What happens to the Km and Vmax in reversible competitive inhibition?

  • Km increases, Vmax increases
  • Km increases, Vmax decreases
  • Km increases, Vmax stays the same
  • Km and Vmax stay the same

4. Chronic alcoholism leaving to liver diseases generally has what effect on CYP2E1?

  • indirect induction leading to mixed metabolism e.g. paracetamol
  • indirect inhibition leading to mixed metabolism e.g. paracetamol
  • direct inhibition leading to competitive metabolism e.g. paracetamol
  • direct induction leading to competitive metabolism e.g. paracetamol

5. Male dominat CYPs in rats include:

  • CYP2C11, CYP3A2
  • CYP2B1, CYP3B1
  • CYP2C7, CYP2C19
  • CYP2C6, CYP1A1

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